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Mammalian cell fusion III. A hela cell inducer of premature chromosome condensation active in cells from a variety of animal species

✍ Scribed by R. T. Johnson; P. N. Rao; H. D. Hughes

Publisher
John Wiley and Sons
Year
1970
Tongue
English
Weight
654 KB
Volume
76
Category
Article
ISSN
0021-9541

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✦ Synopsis

Abstract

The phenomenon of premature chromosome condensation (PCC) is induced in unstimulated horse lymphocytes, bovine spermatozoa, Chinese hamster ovary cells, embryonic chick fibroblasts and erythrocytes, Xenopus kidney and mosquito cells by fusing each of these cell types with HeLa cells blocked in mitosis. Thus it becomes possible to visualize chromosomes even from non‐multiplying cells of heterologous species, such as, chick erythrocytes and bovine spermatozoa.

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