✍ Scribed by Cano, Noël J.M.; Roth, Hubert; Aparicio, Michel; Azar, Raymond; Canaud, Bernard; Chauveau, Philippe; Combe, Christian; Fouque, Denis; Laville, Maurice; Leverve, Xavier M.
No coin nor oath required. For personal study only.
This work aimed to evaluate the role of malnutrition in the increased mortality rate of hemodialysis diabetic patients from a french cooperative series.
Body mass index (bmi), serum albumin, prealbumin, cholesterol, and pre-dialysis creatinine, normalized protein catabolic rate and lean body mass (lbm) were measured in 734 diabetic and 6389 non-diabetic patients (aged 63.4 +/- 12.2 and 62.0 +/- 15.9 years; 1.01 male to 1.40 female ratio). the outcome of 1610 of these patients, including 170 diabetics, was assessed during a 30-month follow-up.
Diabetic as compared to non-diabetic patients showed a significant (p < 10-4) increased bmi (25.9 +/- 5.2 vs. 23.1 +/- 4.3) and cholesterol (5.5 +/- 1.6 vs. 5.3 +/- 1.5 mmol/l), and decreased albumin (37.8 +/- 5.4 vs. 38.9 +/- 5.3 g/l), prealbumin (317 +/- 91 vs. 340 +/- 94 mg/l), creatinine (711 +/- 184 vs. 816 +/- 217 micromol/l) and lbm (76 +/- 18 vs. 87 +/- 21%). normalized protein catabolic rate was similar in the two groups (1.11 +/- 0.31 vs. 1.13 +/- 0.32 g/kg/l). one and two-year survival was 83.7 +/- 2.9% and 65.5 +/- 3.8% in diabetic patients versus 90.3 +/- 0.8% and 79.9 +/- 1.1% in non-diabetics (relative risk 1.26, p < 0.01). independent predictors of survival were age, albumin and prealbumin in non-diabetics and only age in diabetics.
Diabetic patients compared to non-diabetics were characterized by an increased incidence of protein malnutrition and decreased survival. however, the higher death risk associated with diabetes was not related to malnutrition.
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