Malignant transformation of human colon epithelial cells by benzo[c]phenanthrene dihydrodiolepoxides as well as 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine

2-hydroxyamino-1-methyl-6-phenylimidazo

2-hydroxyamino-1-methyl-6-phenylimidazo [4,5-b] pyridine induction of recombinational mutations in mammalian cell lines as detected by dna fingerprinting

✍ Tomoji Kitazawa; Ryo Kominami; Ryuichi Tanaka; Keiji Wakabayashi; Minako Nagao 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 360 KB

## Abstract 2‐Amino‐1‐methyl‐6‐phenylimidazo[4,5‐__b__]pyridine (PhIP) is the most abundant mutagenic heterocyclic amine in cooked foods. Two mouse tumor cell lines, BMT11 and FM3A, were exposed to its proximate form, 2‐hydroxyamino‐1‐methyl‐6‐phenylimidazo[4,5‐__b__]pyridine (__N__‐OH‐PhIP). Fifty