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Malignant peripheral nerve sheath tumors in patients with and without neurofibromatosis

✍ Scribed by P.F. Doorn; W.M. Molenaar; J. Buter; H.J. Hoekstra


Book ID
117568564
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
308 KB
Volume
21
Category
Article
ISSN
0748-7983

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Neurofibromatosis type 1 (NF1) patients have 10% of lifetime risk for developing malignant peripheral nerve sheath tumors (MPNST), one of the most aggressive cancers. We examined the spectrum of constitutional NF1 mutations among 24 NF1 patients with MPNST. We found mutations in 18 patients: four me