Malignant melanoma and lymphoproliferative malignancy: is there a shared aetiology?

✍ Scribed by D.B. Mckenna; V.R. Doherty; K.M. Mclaren; J.A.A. Hunter

• Book ID: 104459518
• Publisher: John Wiley and Sons
• Year: 2000
• Tongue: English
• Weight: 243 KB
• Volume: 143
• Category: Article
• ISSN: 0007-0963
• DOI: 10.1046/j.1365-2133.2000.03610.x

✦ Synopsis

We report seven patients who developed malignant melanoma either coincident with or before the diagnosis of non-Hodgkin's lymphoma or chronic lymphatic leukaemia. One patient died secondary to leukaemia, and chemotherapy-induced immunosuppression may have contributed to the development of metastatic melanoma in another patient. Immunosuppression, exposure to ultraviolet radiation and genetic factors may result in a host environment that is conducive to the development of both tumours in these patients.