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Malignant Glioma: Lessons from Genomics, Mouse Models, and Stem Cells

✍ Scribed by Jian Chen; Renée M. McKay; Luis F. Parada

Book ID: 111930765
Publisher: Elsevier Science
Year: 2012
Tongue: English
Weight: 144 KB
Volume: 149
Category: Article
ISSN: 0092-8674
DOI: 10.1016/j.cell.2012.03.009

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## Abstract The advent of gene targeting has allowed the dissection of many essential cellular pathways, including those involved in cell cycle regulation, signal transduction, and development. However, it is becoming increasingly clear that the simple gene deletion strategy may not be sufficient f