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Malignant fibrous histiocytoma of the sinonasal tract

✍ Scribed by Cheng-Ping Wang; Yih-Leong Chang; Lai-Lei Ting; Tsung-Lin Yang; Jenq-Yuh Ko; Pei-Jen Lou

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
152 KB
Volume
31
Category
Article
ISSN
1043-3074

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✦ Synopsis

Abstract

Background

Sinonasal malignant fibrous histiocytoma (MFH) is rare.

Methods

Twenty‐five patients were registered with a diagnosis of sinonasal MFH at our hospital in the past 30 years. Clinical data were retrospectively reviewed.

Results

Eight tumors were primary MFH and 17 tumors were post‐irradiated MFH, located within the radiation field for previous nasopharyngeal carcinoma. Twenty‐one tumors originated from the maxillary sinus, 3 from the nasopharynx, and 1 from the nasal cavity. Twenty‐three patients underwent surgery but only 12 tumors were removed completely. The 5‐year overall and disease‐free survival rates were 25.1% and 21.5%, respectively. Multivariate analyses showed that previous radiation was the only adverse prognostic factor for disease‐free survival (p = .045). The 5‐year disease‐free survival rates of primary MFH and post‐irradiated MFH were 72.9% and 0%.

Conclusion

In this series, post‐irradiated MFH was more common than primary MFH. The prognosis of post‐irradiated MFH is poor, whereas primary MFH is fair. © 2008 Wiley Periodicals, Inc. Head Neck, 2009

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