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Malignancy associated changes in bronchial epithelial cells and clinical application as a biomarker

✍ Scribed by Ikeda, Norihiko; MacAulay, Calum; Lam, Stephen; LeRiche, Jean; Payne, Peter; Garner, David; Konaka, Chimori; Kato, Harubumi; Palcic, Branko

Book ID
118575181
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
78 KB
Volume
19
Category
Article
ISSN
0169-5002

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## Abstract __O__^6^‐alkylguanine‐DNA alkyltransferase (MGMT) represents the first line of defense against the toxic, mutagenic and carcinogenic effects of __O__^6^‐alkylguanine adducts in DNA. These adducts mediate the biological activity from a series of alkylating agents, such as the tobacco‐spe