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Malignancies in the setting of primary immunodeficiency: Implications for hematologists/oncologists

✍ Scribed by Ralph S. Shapiro

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
315 KB
Volume
86
Category
Article
ISSN
0361-8609

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✦ Synopsis

Abstract

Many primary immunodeficiency disorders (PIDD) are associated with elevated risks for different types of cancer. Defective immunosurveillance mechanisms in PIDD and infection with oncogenic viruses (eg, Epstein Barr, herpesvirus 8) seem to have significant contributory roles in many cases. Non‐Hodgkin lymphoma and Hodgkin disease are two of the most common PIDD‐associated malignancies. The impact of PIDD‐associated malignancy has increased in recent years in parallel with improved patient with PIDD survival and longevity, due largely to effective immunoglobulin replacement therapy. Epidemiologic data, clinical patterns, and management considerations of the common PIDD‐associated cancers are reviewed. Am. J. Hematol., 2011. © 2010 Wiley‐Liss, Inc.

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