Male breast cancer, age and sex chromosome aneuploidy
โ Scribed by Jacobs, P A; Maloney, V; Cooke, R; Crolla, J A; Ashworth, A; Swerdlow, A J
- Book ID
- 119974262
- Publisher
- Nature Publishing Group
- Year
- 2013
- Tongue
- English
- Weight
- 138 KB
- Volume
- 108
- Category
- Article
- ISSN
- 0007-0920
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In lymphocyte cultures, the number of aneuploid cell nuclei increases with proband age mainly because of the loss of sex chromosomes. Since one possible cause of aneuploidy in cell nuclei is chromosomal lag at anaphase, with subsequent chromosome loss via micronucleus formation, we scored 5000 inter
In PHA-cultured lymphocytes, about 8% of metaphases from 32 women were aneuploid compared to 4% of metaphases from 35 men. A significant part of this aneuploidy was characterized by sex chromosome involvement: in women, the loss of gain of X chromosomes; in men, the gain of X chromosomes and the los