Malaria treatment failure with novel mutation in the Plasmodium falciparum dihydrofolate reductase (pfdhfr) gene in Kolkata, West Bengal, India

Two mutations in dihydrofolate reductase

Two mutations in dihydrofolate reductase combined with one in the dihydropteroate synthase gene predict sulphadoxine–pyrimethamine parasitological failure in Ugandan children with uncomplicated falciparum malaria

✍ Ambrose O. Talisuna; Anne Nalunkuma-Kazibwe; Peter Langi; Theonest K. Mutabingwa 📂 Article 📅 2004 🏛 Elsevier Science 🌐 English ⚖ 87 KB

The point mutations in the Plasmodium falciparum dihydrofolate reductase (dhfr) and the dihydropteroate synthase (dhps) genes that are linked to sulphadoxine-pyrimethamine (SP) resistance in vitro have been well characterised. To determine whether a few of these mutations could predict SP treatment