Malakoplakia presenting as an enlarging neck mass: Case presentation and review of the literature

✍ Scribed by Montey Garg; Karen A. Eley; Stephen E. Bond; Ketan A. Shah; Lisa Browning; Stephen R. Watt-Smith

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 356 KB
• Volume: 32
• Category: Article
• ISSN: 1043-3074
• DOI: 10.1002/hed.21183

✦ Synopsis

Abstract

Background.

Malakoplakia is a very rare chronic inflammatory disorder, first described in 1902. In 75% of cases, the condition affects the genitourinary tract. Five cases of malakoplakia affecting the neck were previously reported in the literature.

Methods and Results.

An 83‐year‐old woman presented with an enlarging mass in the posterior triangle of the neck that was histologically confirmed as malakoplakia. Presenting features are often nonspecific, and the diagnosis is dependent on histological findings. The characteristic microscopic findings are of Michaelis–Gutmann (M‐G) bodies that stain positive with periodic acid–Schiff reagent, von Kossa's reaction for calcium, and Perl's ferrocyanide reaction to ferric iron.

Conclusion.

Although rare, a diagnosis of malakoplakia should be considered in patients with an enlarging mass. This may mimic the presentation of malignancy, particularly in patients in whom erosion through skin occurs, and histological confirmation is advocated. © 2009 Wiley Periodicals, Inc. Head Neck 32:1269–1272, 2010