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Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

✍ Scribed by Fitzgerald, Katherine A.; Palsson-McDermott, Eva M.; Bowie, Andrew G.; Jefferies, Caroline A.; Mansell, Ashley S.; Brady, Gareth; Brint, Elizabeth; Dunne, Aisling; Gray, Pearl; Harte, Mary T.; McMurray, Diane; Smith, Dirk E.; Sims, John E.; Bird, Timothy A.; O'Neill, Luke A. J.


Book ID
109775810
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
292 KB
Volume
413
Category
Article
ISSN
0028-0836

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The Toll-like receptor 4 (TLR4) that recognizes endotoxin, a trigger of inflammation in alcoholic liver disease (ALD), activates two signaling pathways utilizing different adapter molecules: the common TLR adapter, myeloid differentiation factor 88 (MyD88), or Toll/interleukin immuneresponse-domain-