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Making the Auroras glow: regulation of Aurora A and B kinase function by interacting proteins

✍ Scribed by Mar Carmena; Sandrine Ruchaud; William C Earnshaw


Book ID
113525061
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
343 KB
Volume
21
Category
Article
ISSN
0955-0674

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## Abstract Aurora‐A is an oncogenic kinase that plays essential roles in mitosis as well as cell survival. Aurora‐A interacting protein (AIP) was identified as a negative regulator of Aurora‐A with its ectopic over expression inducing destabilization of Aurora‐A protein. Here we present evidence t