Making new out of old: Recycling and modification of an ancient protein translocation system during eukaryotic evolution : Mechanistic comparison and phylogenetic analysis of ERAD, SELMA and the peroxisomal importomer
✍ Scribed by Kathrin Bolte; Nicole Gruenheit; Gregor Felsner; Maik S. Sommer; Uwe-G. Maier; Franziska Hempel
- Book ID
- 102757498
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 588 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0265-9247
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✦ Synopsis
Abstract
At first glance the three eukaryotic protein translocation machineries – the ER‐associated degradation (ERAD) transport apparatus of the endoplasmic reticulum, the peroxisomal importomer and SELMA, the pre‐protein translocator of complex plastids – appear quite different. However, mechanistic comparisons and phylogenetic analyses presented here suggest that all three translocation machineries share a common ancestral origin, which highlights the recycling of pre‐existing components as an effective evolutionary driving force.
Editor's suggested further reading in BioEssays ERAD ubiquitin ligases Abstract