Major histocompatibility complex regulation of interleukin-5 production in the mouse

✍ Scribed by Francesco Dieli; Guido Sireci; Domenico Lio; Cesira T. Bonanno; Alfredo Salerno

• Publisher: John Wiley and Sons
• Year: 1993
• Tongue: English
• Weight: 644 KB
• Volume: 23
• Category: Article
• ISSN: 0014-2980
• DOI: 10.1002/eji.1830231125

✦ Synopsis

Major histocompatibility complex regulation of interleukin-5 production in the mouse*

Lymph node cells of CBA (H-2k), but not of BALB/c (H-2d) mice immunized epicutaneously with picryl chloryde secrete interleukin (1L)-5 when stimulated with the specific antigen in vitro. The low IL-5 production in BALBk mice persists when either picryl chloride or the unrelated antigen oxazolone are used, when the amount of antigen in vitro is varied and when a secondary response is studied. The difference in IL-5 production maps to the major histocompatibility complex (MHC) in the congenic BALB/b, BALB/c and BALB/k mice. Furthermore, lymph node cells from (k x d) F1 mice produce IL-5 when stimulated by antigen presented on H-2k but not on H-2d antigen-presenting cells. Finally, the low IL-5 production in vitro in BALB/c mice is correlated with low picryl-specific IgA levels in vivo, which otherwise are ten times greater in CBA and BALB/k mice. The influence of MHC on IL-5 production and IgA secretion in the mouse might be a possible basis for the association of MHC with IgA deficiency in humans.