Major histocompatibility complex associations with primary antiphospholipid syndrome
β Scribed by R. A. Asherson; D. G. Doherty; D. Vergani; M. A. Khamashta; G. R. V. Hughes
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 193 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0004-3591
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## Abstract ## Objective We have previously identified a singleβnucleotide polymorphism (SNP) haplotype involving the lymphotoxin Ξ± (LTA) and tumor necrosis factor (TNF) loci (termed haplotype LTAβTNF2) on chromosome 6 that shows differential association with rheumatoid arthritis (RA) on HLAβDRB1\
## Objective: To determine whether major histocompatibility complex (mhc) polymorphisms are associated with a good or poor response to infliximab therapy in patients with rheumatoid arthritis (ra). ## Methods: Seventy-eight infliximab-treated patients with ra were genotyped for hla-drb1, hla-dqa1