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Major gene for percent of oxygen saturation of arterial hemoglobin in Tibetan highlanders

✍ Scribed by Cynthia M. Beall; John Blangero; Sarah Williams-Blangero; Melvyn C. Goldstein

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
450 KB
Volume
95
Category
Article
ISSN
0002-9483

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✦ Synopsis

Abstract

This report employs a statistical genetic approach to analyze quantitative oxygen transport variables in a high‐altitude (4,850–5,450 m) native Tibetan population and demonstrates the presence of a major gene influencing % O~2~ saturation of arterial hemoglobin. This result suggests the hypothesis that individuals with the dominant allele for higher % O~2~ saturation have a selective advantage at high altitude. Studies of the biologically distinctive Himalayan and Andean populations have greatly influenced thinking about ongoing human evolution and adaptation; this is the first statistical evidence for a major gene enhancing oxygen transport in a highaltitude native population. © 1994 wiley‐Liss, Inc.

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