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Major depressive disorder in the elderly: The relationship between age of onset and cognitive impairment

✍ Scribed by A. Steingart; Dr. N. Herrmann

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
500 KB
Volume
6
Category
Article
ISSN
0885-6230

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✦ Synopsis

In order to determine if later age of onset of depression in the elderly is associated with increased cognitive impairment, the scores on the Mini-Mental State Examinations of 41 elderly depressed patients were correlated with the ages of onset of depression. All subjects, average age 74.7, were referred to a psychiatric day hospital for treatment of a major depressive disorder, and all scored at least 14 on the 17-item Hamilton Depression Rating Scale. The ages of first mental health contact and symptom onset were significantly negatively correlated with Mini-Mental State scores (p = 0.021 and 0.035 respectively) after the confounding effect of age was adjusted for using partial correlations. The relation between late-onset depression and cognitive impairment lends support to the hypothesis that late-onset depressive disorders in the elderly may be associated with occult brain disease.

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