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Major active components in grapefruit, orange, and apple juices responsible for OATP2B1-mediated drug interactions

✍ Scribed by Shirasaka, Yoshiyuki; Shichiri, Megumi; Mori, Takanori; Nakanishi, Takeo; Tamai, Ikumi


Book ID
118763273
Publisher
John Wiley and Sons
Year
2013
Tongue
English
Weight
299 KB
Volume
102
Category
Article
ISSN
0022-3549

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To investigate the potential interaction between selected ingredients of grapefruit juice and, the transport of talinolol, a P-gp substrate, across Caco-2 cells monolayers was determined in the absence and presence of distinct concentrations of grapefruit juice, bergamottin, 6 0 ,7 0 -dihydroxyberga