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Maintenance therapy for ulcerative colitis has no impact on changes in the extent of ulcerative colitis

✍ Scribed by N. Eleftheriadis; G. Lambrecht; G. D’Haens; F. Baert; M. Cabooter; E. Louis; G. Van Assche; P. Schurmans; P. Caenepeel; M. Van Outryve; P. Lammens; A. Van Gossum; M. De Vos


Book ID
119223038
Publisher
Oxford University Press
Year
2007
Tongue
English
Weight
343 KB
Volume
1
Category
Article
ISSN
1873-9946

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Thiopurine maintenance therapy for ulcer
✍ Hiroyuki Hanai; Takayuki Iida; Ken Takeuchi; Osamu Arai; Fumitoshi Watanabe; Jin 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 270 KB

Background: 6-Mercaptopurine (6-MP) is an effective maintenance medication in patients with ulcerative colitis (UC), but toxic effects like myelosuppression limit its clinical benefit. In the blood, 6-thioguanine (6-TGN) is formed from 6-MP and mediates the therapeutic efficacy and most of the toxic