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Maintenance of Susceptibility to Neurodegeneration Following Intrastriatal Injections of Quinolinic Acid in a New Transgenic Mouse Model of Huntington's Disease

✍ Scribed by Å. Petersén; K. Chase; Z. Puschban; M. DiFiglia; P. Brundin; N. Aronin


Book ID
115607711
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
176 KB
Volume
175
Category
Article
ISSN
0014-4886

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## Abstract Symptoms in the early stages of Huntington's disease (HD) are assumed to reflect basal ganglia circuit dysfunction secondary to degeneration of striatal projections to the external segment of the globus pallidus (GPe). The hypothesis that GPe lesion would ameliorate HD symptoms by “norm