Maintenance of high-density lipoprotein blood levels prior to spontaneous abortion in pig-tailed macaques (Macaca nemestrina)
✍ Scribed by Dr. Harvey S. Schiller; Gene P. Sackett; W. Timm Frederickson; Linda J. Risler
- Book ID
- 101452447
- Publisher
- John Wiley and Sons
- Year
- 1983
- Tongue
- English
- Weight
- 397 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0275-2565
No coin nor oath required. For personal study only.
✦ Synopsis
Blood was drawn throughout the first half of the pregnancies of 24 pig-tailed macaques (Macaca nernestrinal to evaluate longitudinal high-density lipoprotein (HDL) changes. In all 15 normal pregnancies, HDL decreased a t least 50%; the mean value for the group fell from 0.45 gmiliter to 0.17 gm/liter. HDL began to fall after about four weeks of pregnancy. However, no comparable HDL change occurred in nine pregnancies that terminated in spontaneous abortions. This lack of an HDL decrease was unexpected. Subsequent studies showed that the predominant decrease was in the HDL, subfraction.
The data indicate that the normal physiologic metabolism or utilization of HDL is aberrant early in pregnancies ending in spontaneous abortions and may be due to a dysfunctional fetal-placental unit.