Maintenance, equipment and operational improvements within an established Fermentation Pilot Plant

✍ Scribed by B. H. Junker; J. Lynch; J. Leporati; J. Schmitt; J. Gieger; T. Garah; M. Stober; P. Salmon

• Book ID: 104744303
• Publisher: Springer
• Year: 1995
• Tongue: English
• Weight: 858 KB
• Volume: 13
• Category: Article
• ISSN: 1615-7605
• DOI: 10.1007/bf00369558

✦ Synopsis

The Merck Research Laboratories' Fermentation Pilot Plant was constructed and commissioned in the early 1980's. It is a highly instrumented and automated facility which serves to maximize data collection for a variety of experimental batches. To continue successful and versatile operation as the facility ages, various improvements in equipment, maintenance, instrumentation, cleaning and sterility have been implemented. The goals were to improve flexibility, minimize down time, increase measurement accuracy and reduce contamination to enhance facility output for process development and clinical material production.