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Maid (GCIP) is involved in cell cycle control of hepatocytes

✍ Scribed by Eva Sonnenberg-Riethmacher; Torsten Wüstefeld; Michaela Miehe; Christian Trautwein; Dieter Riethmacher

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
863 KB
Volume
45
Category
Article
ISSN
0270-9139

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✦ Synopsis

The function of Maid (GCIP), a cyclinD-binding helix-loop-helix protein, was analyzed by targeted disruption in mice. We show that Maid function is not required for normal embryonic development. However, older Maid-deficient mice-in contrast to wild-type controlsdevelop hepatocellular carcinomas. Therefore, we studied the role of Maid during cell cycle progression after partial hepatectomy (PH). Lack of Maid expression after PH was associated with a delay in G1/S-phase progression as evidenced by delayed cyclinA expression and DNA replication in Maid-deficient mice. However, at later time points liver mass was restored normally. Conclusion: These results indicate that Maid is involved in G1/S-phase progression of hepatocytes, which in older animals is associated with the development of liver tumors. (HEPATOLOGY 2007;45:404-411.

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