Magnetization transfer effect on the creatine methyl resonance studied by CW off-resonance irradiation in human skeletal muscle on a clinical MR system
✍ Scribed by W. Klaas Jan Renema; Dennis W.J. Klomp; Mariëlle E.P. Philippens; Adrianus J. van den Bergh; Bé Wieringa; Arend Heerschap
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 246 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0740-3194
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✦ Synopsis
Abstract
Magnetization transfer (MT) between the mobile (MR‐visible) spin pool and immobile (MR‐invisible) spin pool of creatine (Cr) was studied on a clinical 1.5 T MR scanner in human skeletal muscle using continuous wave (CW) pre‐irradiation as the saturation method for the immobile pool. For this purpose, only slight modifications to the MR system were made. A specially designed electronic circuit was used to couple a CW amplifier to the RF channel of the scanner. The CW pulse power (γ__B__~2~/2π) and pulse length were determined to be approximately 550 Hz and 3 s, respectively, for optimal signal attenuation of the Cr methyl signal. The bound Cr fraction in human gastrocnemius muscle was determined to be 0.4–1.3% using a two‐pool exchange model function to describe the MT effect. Magn Reson Med 50:468–473, 2003. © 2003 Wiley‐Liss, Inc.