✦ LIBER ✦

Magnetization transfer contrast imaging in Niemann pick type C mouse liver

✍ Scribed by Jingyu Guo; Robert Erickson; Theodore Trouard; Jean-Philippe Galons; Robert Gillies

Publisher: John Wiley and Sons
Year: 2003
Tongue: English
Weight: 790 KB
Volume: 18
Category: Article
ISSN: 1053-1807
DOI: 10.1002/jmri.10404

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Purpose

To investigate livers of mice afflicted with Niemann Pick type C (NP‐C) disease using magnetization transfer contrast (MTC) imaging and to test the hypothesis that the MT ratio reproducibly changes during disease progression.

Background

NP‐C is a heritable defect of lipid metabolism that results in the accumulation of unesterified cholesterol and gangliosides in virtually all cells. Symptoms predominate in brain and liver, which have high endogenous rates of lipid turnover. It is fatal to children, usually early in the second decade of life. Previous work has shown that the efficiency of magnetization transfer (MT) can be affected by cholesterol and collagen in tissues. The MT ratio (MTR) was calculated and compared during growth and therapy of diseased and control mice.

Results

Significant differences in the MTR were observed between livers of diseased and control mice. These ratios were consistent with collagen deposition associated with fibrosis, and not the accumulation of unesterified cholesterol in this organ.

Conclusion

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