Magnetization transfer changes in the normal appering white matter precede the appearance of enhancing lesions in patients with multiple sclerosis

Use of ultrasmall superparamagnetic part

Use of ultrasmall superparamagnetic particles of iron oxide (USPIO)-enhanced MRI to demonstrate diffuse inflammation in the normal-appearing white matter (NAWM) of multiple sclerosis (MS) patients: An exploratory study

✍ Machteld M. Vellinga; Hugo Vrenken; Hanneke E. Hulst; Chris H. Polman; Bernard M 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 198 KB 👁 1 views

## Abstract ## Purpose To explore ultrasmall superparamagnetic particles of iron oxide (USPIO) as a marker for diffuse inflammation in multiple sclerosis (MS) normal‐appearing white matter (NAWM), using quantitative MRI. Disease activity in the NAWM of MS patients partly explains why MRI lesion bu