Magnetization transfer affects the proton creatine/phosphocreatine signal intensity: In vivo demonstration in the rat brain
✍ Scribed by Wolfgang Dreher; David G. Norris; Dieter Leibfritz
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 384 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0740-3194
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
The effect of off‐resonance preirradiation on proton spectra acquired from the healthy rat brain at 4.7 T is examined using a PRESS sequence. The creatin/phosphocreatine (Cr/PCr) signal at 3.0 ppm decreases in signal intensity for offset frequencies between ±10 kHz. This cannot be explained by RF bleedover, but is attributed to magnetization transfer between two pools of Cr/PCr, one with a long T~2~ relaxation time giving the observed NMR signal, the other corresponding to a broad resonance line being completely or partially saturated by off‐resonance preirradiation. Possible interpretations of these results are discussed.