✦ LIBER ✦

Magnetization exchange with water and T1 relaxation of the downfield resonances in human brain spectra at 3.0 T

✍ Scribed by Erin L. MacMillan; Daniel G. Q. Chong; Wolfgang Dreher; Anke Henning; Chris Boesch; Roland Kreis

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 584 KB
Volume: 65
Category: Article
ISSN: 0740-3194
DOI: 10.1002/mrm.22813

No coin nor oath required. For personal study only.

✦ Synopsis

The use of water suppression for in vivo proton MR spectroscopy diminishes the signal intensities from resonances that undergo magnetization exchange with water, particularly those downfield of water. To investigate these exchangeable resonances, an inversion transfer experiment was performed using the metabolite cycling technique for non-watersuppressed MR spectroscopy from a large brain voxel in 11 healthy volunteers at 3.0 T. The exchange rates of the most prominent peaks downfield of water were found to range from 0.5 to 8.9 s 21 , while the T 1 relaxation times in absence of exchange were found to range from 175 to 525 ms. These findings may help toward the assignments of the downfield resonances and a better understanding of the sources of contrast in chemical exchange saturation transfer imaging.

📜 SIMILAR VOLUMES

Interregional variation of longitudinal

Interregional variation of longitudinal relaxation rates in human brain at 3.0 T: Relation to estimated iron and water contents

✍ Neil Gelman; James R. Ewing; Jay M. Gorell; Eric M. Spickler; Enez G. Solomon 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 257 KB 👁 2 views

Measurement of longitudinal (T1) relaxat

Measurement of longitudinal (T1) relaxation in the human lung at 3.0 Tesla with tissue-based and regional gradient analyses

✍ Michael B. Nichols; Cynthia B. Paschal 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 173 KB 👁 1 views

## Abstract ## Purpose The purpose of this study is to measure the longitudinal (T1) relaxation time of human lung parenchyma at 3.0 Tesla (T), independent of large vessel signal, and to examine T1 as a function of position in gravitational, isogravitational, and radial planes. ## Materials and M

31P Magnetic resonance spectroscopic ima

31P Magnetic resonance spectroscopic imaging with polarisation transfer of phosphomono- and diesters at 3 T in the human brain: relation with age and spatial differences

✍ J. P. Wijnen; T. W. J. Scheenen; D. W. J. Klomp; A. Heerschap 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 743 KB

Short echo time 1H MRSI of the human bra

Short echo time 1H MRSI of the human brain at 3T with adiabatic slice-selective refocusing pulses; reproducibility and variance in a dual center setting

✍ Jannie P. Wijnen; Jack J.A. van Asten; Dennis W.J. Klomp; Torill E. Sjobakk; Ing 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 356 KB 👁 1 views

## Abstract ## Purpose: To assess the reproducibility of ^1^H‐MR spectroscopic imaging (MRSI) of the human brain at 3T with volume selection by a double spin echo sequence for localization with adiabatic refocusing pulses (semi‐LASER). ## Materials and Methods: Twenty volunteers in two different