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Magnetic resonance relaxation times of normal tissue in the course of chemotherapy: a study in patients with bone sarcoma

✍ Scribed by H. C. Holscher; H. -J. Woude; J. Hermans; M. A. Nooy; J. Doornbos; J. L. Bloem

Publisher
Springer
Year
1994
Tongue
English
Weight
484 KB
Volume
23
Category
Article
ISSN
0364-2348

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✦ Synopsis

To study the effect of chemotherapy on normal fat, skeletal muscle, and bone marrow, T1 and T2 relaxation times were measured in 15 patients with bone sarcoma before and after each cycle of preoperative chemotherapy. A section plane containing the tumor and if possible the nonaffected extremity was imaged with combined multiecho spin echo and inversion recovery pulse sequences. T1 and T2 relaxation times were calculated in the normal-appearing tissues. Although some variation was found in the values in the individual patient and between patients, no systematic changes of relaxation times of fat, muscle, or bone marrow occurred in the course of treatment. We conclude that the chemotherapy used in bone sarcoma has no effect on relaxation times of normal fat, muscle, and bone marrow, and that therefore these tissues may serve as a reference for the signal intensity of tumor.

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