𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Magnetic resonance microscopy quantifies the disease progression in Marfan syndrome mice

✍ Scribed by Vitalii V. Itskovich; Mark Lieb; Juan Gilberto S. Aguinaldo; Daniel D. Samber; Francesco Ramirez; Zahi A. Fayad

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
535 KB
Volume
17
Category
Article
ISSN
1053-1807

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Purpose

To use noninvasive magnetic resonance microscopy (MRM) to examine aneurysmal disease in the mouse model of Marfan syndrome (MFS).

Materials and Methods

A total of eight wild‐type (WT) and MFS mice were imaged using MRM; four of them at three different time points over an 8‐week period and the remaining animals were imaged at one time point. The maximal cross‐sectional area of the aorta was measured by manual tracing and by automated means from combined cardiac and respiratory‐gated bright‐blood images. Relationships between aortic size and age and the differences between WT and mutant mice aortic size were established.

Results

Maximal cross‐sectional aortic areas differed significantly (P < 0.05) between WT and mutant mice for all time points, with MFS mice having larger aortic size. There was a positive correlation between aortic size and age in MFS mice (r = 0.80) with a significant increase from the 14th to the 22nd week (P < 0.05).

Conclusion

MRM detected the differences in aortic size between WT and mutant mice over time, demonstrating a potential for noninvasive technique for the assessment of potential therapies in MFS mice. J. Magn. Reson. Imaging 2003;17:435–439. © 2003 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Serial, noninvasive, in vivo magnetic re
Serial, noninvasive, in vivo magnetic resonance microscopy detects the development of atherosclerosis in apolipoprotein E-deficient mice and its progression by arterial wall remodeling
✍ Robin P. Choudhury; Zahi A. Fayad; J. Gilberto Aguinaldo; Vitalii V. Itskovich; 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 544 KB

## Abstract ## Purpose To test the ability of serial, in vivo magnetic resonance microscopy (MRM) to detect the development of atherosclerosis and quantify its progression in apolipoprotein E‐deficient mice. ## Materials and Methods The abdominal aortae of six ApoE^−/−^ and three wild‐type (WT)

Degenerative joint disease in the guinea
Degenerative joint disease in the guinea pig. Use of magnetic resonance imaging to monitor progression of bone pathology
✍ Paul J. Watson; Laurance D. Hall; Archie Malcolm; Jenny A. Tyler 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 966 KB

## Abstract __Objective__. The suitability of magnetic resonance imaging (MRI) for serial monitoring of bone pathology in the guinea pig stifle joint, an in vivo model of osteoarthritis, was investigated. __Methods__. MR images were compared with histologic features and radiographs of 1‐mm‐thick s

In Vivohepatic energy metabolism during
In Vivohepatic energy metabolism during the progression of alcoholic liver disease: A noninvasive 31p nuclear magnetic resonance study in rats
✍ Hisao Takahashi; Yves Geoffrion; Keith W. Butler; Samuel W. French 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 971 KB

We investigated serially in vivo the ratios of phosphorylated metabolites and the intracellular pH in the livers of rats fed ethanol chronically to evaluate the relation between changes in energy metabolism and the progression of alcoholic liver disease with nuclear magnetic resonance spectroscopy.

Magnetic resonance imaging abnormalities
Magnetic resonance imaging abnormalities of the brain in Goldberg-Shprintzen syndrome (Hirschsprung disease, microcephaly, and iris coloboma)
✍ Ohnuma, Kei; Imaizumi, Kiyoshi; Masuno, Mitsuo; Nakamura, Mihoko; Kuroki, Yoshik 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 23 KB 👁 3 views

Inheritance of the syndrome is suggested to be autosomal recessive. Electroencephalogram (EEG) was abnormal in four of five individuals studied. The brain computed tomography (CT) was abnormal in 9 of 10 individuals and the abnormalities included a small and thick vault, irregular margins of the ven

A new spin on an old model: In vivo eval
A new spin on an old model: In vivo evaluation of disease progression by magnetic resonance imaging with respect to standard inflammatory parameters and histopathology in the adjuvant arthritic rat
✍ Peer B. Jacobson; Sheryl J. Morgan; Denise M. Wilcox; Phong Nguyen; Christine A. 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 994 KB

Objective. To noninvasively examine the pathogenesis of rat adjuvant-induced arthritis (AIA) by magnetic resonance imaging (MRI), and to correlate MRI indices of disease progression with classic inflammatory parameters and histologic evaluation. Methods. AIA was established in male Lewis rats follo