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Magnetic resonance imaging of denervation-induced muscle atrophy: Effects of clenbuterol in the rat

✍ Scribed by Michael D. Cockman; Melissa B. Jones; Marla C. Prenger; Russell J. Sheldon

Publisher: John Wiley and Sons
Year: 2001
Tongue: English
Weight: 759 KB
Volume: 24
Category: Article
ISSN: 0148-639X
DOI: 10.1002/mus.1200

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✦ Synopsis

Abstract

We show that magnetic resonance imaging (MRI) can be used to quantify the amount of muscle in the lower legs of adult rats and to noninvasively monitor the onset and progression of denervation‐induced atrophy. Muscle cross‐sectional areas determined from 2D gradient‐echo MR images allow longitudinal quantification of the protective effects of a β~2~‐adrenergic agonist clenbuterol. We also show that the estimation of clenbuterol's efficacy is improved by computation of the muscle volume. Rapid animal throughput and the ability to accurately estimate efficacy make MRI an attractive technology for studying skeletal muscle atrophy and hypertrophy, allowing the evaluation of potential therapies in longitudinal studies. © 2001 John Wiley & Sons, Inc. Muscle Nerve 24: 1647–1658, 2001

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