𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Magnetic nanoparticles with dual functional properties: Drug delivery and magnetic resonance imaging

✍ Scribed by Tapan K. Jain; John Richey; Michelle Strand; Diandra L. Leslie-Pelecky; Chris A. Flask; Vinod Labhasetwar

Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
544 KB
Volume
29
Category
Article
ISSN
0142-9612

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✦ Synopsis

There is significant interest in recent years in developing magnetic nanoparticles (MNPs) having multifunctional characteristics with complimentary roles. In this study, we investigated the drug delivery and magnetic resonance imaging (MRI) properties of our novel oleic acid-coated iron-oxide and pluronic-stabilized MNPs. The drug incorporation efficiency of doxorubicin and paclitaxel (alone or in combination) in MNPs was 74–95%; the drug release was sustained and the incorporated drugs had marginal effects on physical (size and zeta potential) and magnetization properties of the MNPs. The drugs in combination incorporated in MNPs demonstrated highly synergistic antiproliferative activity in MCF-7 breast cancer cells. The T
2 relaxivity (r
2) was higher for our MNPs than Feridex IV™, whereas the T
1 relaxivity (r

  1. was better for Feridex IV than for our MNPs, suggesting greater sensitivity of our MNPs than Feridex IV in T
    2 weighted imaging. The circulation half-life (t
    1/2), determined from the changes in the MRI signal intensity in carotid arteries in mice, was longer for our MNPs than Feridex IV (t
    1/2
    =31.2 vs. 6.4min). MNPs with combined characteristics of MRI and drug delivery could be of high clinical significance in the treatment of various disease conditions.

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