Magnetic HP-β-CD Composite Nanoparticle: Synthesis, Characterization and Application as a Carrier of Doxorubicin in vitro
✍ Scribed by Hua ZHANG; Ming-Li PENG; Ya-Li CUI; Chao CHEN
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 98 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0256-7660
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✦ Synopsis
Abstract
Hydroxylpropyl‐β‐cyclodextrin (HP‐β‐CD) was introduced to the surface of magnetic nanoparticles in the presence of NH~3~·H~2~O to synthesize magnetic HP‐β‐CD composite nanoparticles, which were used as a carrier in magnetic targeted drug delivery. The composite nanoparticles were characterized by FTIR, ICP‐AES, TEM and VSM. The results showed that the iron content in the composite nanoparticles was 55.4%. The range of size is 10–20 nm and the magnetization is 59.9 emu/g. The capacity of composite nanoparticles for doxorubicin adsorption is 87.8 µg/mg after incubation for 72 h. The cumulative percentage of released doxorubicin in PBS buffer (pH=7.4) in 1, 4, 10 d were 35.5%, 49.3% and 76.5%, respectively. Thus, the magnetic HP‐β‐CD composite nanoparticles could be a potential carrier in the magnetic targeted drug delivery.