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Magnesium promoted cyclopropanation reactions of allylic alcohols

โœ Scribed by Carsten Bolm; Doris Pupowicz

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
205 KB
Volume
38
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

Treatment of allylic alcohols 1 with various magnesium reagents in the presence of alkyl dihalides affords the corresponding cyclopropyl alcohols 2. Reactions occur under mild conditions, and excellent diastereoselectivities have been achieved.

๐Ÿ“œ SIMILAR VOLUMES

Dichlorocarbene cyclopropanation of ally
Dichlorocarbene cyclopropanation of allylic alcohols
โœ Fariborz Mohamadi; W.Clark Still ๐Ÿ“‚ Article ๐Ÿ“… 1986 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 170 KB

Dichlorocarbene reacts with secondary allylic alcohols to form largely a single diastereomeric cyclopropane regardless of the olefin substitution pattern at the position beta to the carbinol carbon.