MAGE, BAGE and GAGE genes encode tumor-associated antigens that are presented by HLA class I molecules and recognized by CD8 ุ cytolytic T lymphocytes. These antigens are currently regarded as promising targets for active, specific tumor immunotherapy because MAGE, BAGE and GAGE genes are expressed
MAGE, BAGE and GAGE genes experiences in fresh epithelial ovarian carcinomas
โ Scribed by Vincenzo Russo; Piero Dalerba; Axel Ricci; Cristina Bonazzi; B. E. Leone; Costantino Mangioni; Paola Allavena; Claudio Bordignon; Catia Traversari
- Book ID
- 101233567
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- French
- Weight
- 306 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0020-7136
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## Background: It has been found that the members of the bage, mage, and gage gene families are expressed almost exclusively in neoplastic tissues. normal tissues, except testis and placenta, are negative. therefore, the expression of these genes may serve as a useful diagnostic marker in detecting
The MAGE, BAGE, and GAGE gene families code for distinct, tumor specific antigens that are recognized by cytotoxic T lymphocytes in the context of HLA molecules. The purpose of this study was to analyze MAGE, BAGE, and GAGE gene expression in the two major histologic types of esophageal carcinoma, s