Macrophage pacification reduces pancreatitis-induced hepatocellular injury through downregulation of hepatic TNF and IL-1

Macrophage pacification reduces rodent p

Macrophage pacification reduces rodent pancreatitis-induced hepatocellular injury through down-regulation of hepatic tumor necrosis factor α and interleukin-1β

✍ Jun Yang; Woody Denham; Gay Carter; Kevin J. Tracey; James Norman 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 131 KB

Overproduction of tumor necrosis factor ␣ (TNF-␣), interleukin-1␤ (IL-1␤), and nitric oxide (NO) is believed to be detrimental during the progression of acute pancreatitis, yet little is known about the hepatic production of these mediators and their role in mediating pancreatitis-induced hepatic dy