Macrophage development: I. Rationale for usingGriffonia simplicifolia isolectin B4 as a marker for the line
✍ Scribed by Sorokin, Sergei P. ;Hoyt, Richard F.
- Book ID
- 102745553
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 954 KB
- Volume
- 232
- Category
- Article
- ISSN
- 0003-276X
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✦ Synopsis
The isolectin B, of Griffonia simplicifolia (GSA I-B,) binds to cell membrane glycoconjugates bearing terminal alpha-D-galactose, which macrophages possess. We have investigated the merits of its use as a marker for cells of this lineage when examining the early origin of macrophage populations in rat embryos, the stages and time scale of transformation from precursor forms to active, matured cells, and the response of precursors and macrophages to colonystimulating blood factors, the last two studies conducted in organ cultures of prenatal lungs. In the present instance, GSA I-B, was used either coupled with flu-