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Macrophage-derived transforming growth factor-β1 induces hepatocellular injury via apoptosis in rat severe acute pancreatitis

✍ Scribed by Yuichi Hori; Yoshifumi Takeyama; Takashi Ueda; Masayuki Shinkai; Kozo Takase; Yoshikazu Kuroda


Book ID
117849179
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
166 KB
Volume
127
Category
Article
ISSN
0039-6060

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## Abstract Transforming growth factor‐β1 (TGFβ1) is a multifunctional cytokine that is over expressed during liver hepatocytes injury and regeneration. SV40‐transformed CWSV‐1 rat hepatocytes that are p53‐defective undergo apoptosis in response to choline deficiency (CD) or TGFβ1, which mediates C