Macrophage antitumor activity: impaired responsiveness to interferon-γ of macrophages from genetically defective mice

✍ Scribed by Diana Boraschi; Stefano Censini; Aldo Tagliabue

• Book ID: 102159935
• Publisher: John Wiley and Sons
• Year: 1984
• Tongue: English
• Weight: 333 KB
• Volume: 14
• Category: Article
• ISSN: 0014-2980
• DOI: 10.1002/eji.1830141119

✦ Synopsis

Macrophage antitumor activity: impaired responsiveness to interferon-y of macrophages from genetically defective mice

Macrophages (MQ,) from the genetically defective mouse strains C3H/HeJ, A/J and P/ J were unable to develop high levels of antitumor activities when stimulated either with immune recombinant interferon gamma (IFN-y) or with nonimmune IFN-a and IFN-b, as compared to MQ, or normal C3H/HeN mice. IFN-y appeared to be an exceptionally good activator of C3HIHeN M@, as it could induce tumoricidal capacities 3000 times more efficiently than nonimmune IFN. The high efficiency of IFN-y as MQ, activator was indeed confirmed on defective MQ,. In fact, at high doses IFNy could also induce significant levels of both cytolytic and cytostatic activity in MQ, of AIJ and P/J mice, although it could not increase cytotoxic activities of C3HIHeJ MQ,.