Macromolecular engineering of polylactones and polylactides. XXV. Synthesis and characterization of bioerodible amphiphilic networks and their use as controlled drug delivery systems
✍ Scribed by I. Barakat; Ph. Dubois; Ch. Grandfils; R. Jérôme
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 217 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0887-624X
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✦ Synopsis
Well-defined ␣,-methacryloyl poly--caprolactone (PCL) and poly(D,L)-lactide P(D,L)LA dimacromonomers have been synthesized by living ring-opening polymerization of the parent monomers initiated by diethylaluminum 2-hydroxyethylmethacrylate (Et 2 AlOOO(CH 2 ) 2 OOOC(O)OC(CH 3 )ACH 2 ) and terminated by reaction of the propagating Al alkoxide groups with methacryloyl chloride. These dimacromonomers have been copolymerized with a hydrophilic comonomer, i.e., 2-hydroxyethylmethacrylate, in bulk at 65°C by using benzoyl peroxide as a free-radical initiator. The swelling ability of the amphiphilic PHEMA/PCL or P(D,L)LA networks has been investigated in both aqueous and organic media. Effect of network composition and molecular weight of the dimacromonomer on the swelling kinetics and the equilibrium solvent uptake has been studied. Lipophilic dexamethasone acetate and the hydrophilic sodium phosphate counterpart have been incorporated into the amphiphilic gels and their release has been studied in relation to the gel characteristics.