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Macrocyclic lanthanide complexes as potential contrast agents for NMR imaging

โœ Scribed by S.W.A. Bligh; N. Choi; W.J. Cummins; E.G. Evagorou; J.D. Kelly; M. McPartlin; H.G. Parkes


Book ID
103569560
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
57 KB
Volume
51
Category
Article
ISSN
0162-0134

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Enzyme-responsive MRIcontrast agents containing a "self-immolative" benzylcarbamate moiety that links the MRI-reporter lanthanide complex to a specific enzyme substrate have been developed. The enzymatic cleavage initiates an electronic cascade reaction that leads to a structural change in the Ln II