𝔖 Bobbio Scriptorium
✦   LIBER   ✦

M+4 stable isotope labeling of levovirin and M+7 and carbon-14 labeling of levovirin valinate pro-drug

✍ Scribed by Steve A. de Keczer; Mohammad R. Masjedizadeh; Shao-Yong Wu; Teresa Lara-Jaime; Kate Comstock; Charles Dvorak; Yu-Ying Liu; Walter Berger

Publisher
John Wiley and Sons
Year
2006
Tongue
French
Weight
177 KB
Volume
49
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

[M+4]‐labeled levovirin 5 (231 mg) was synthesized as an MS reference compound from [M+4] triazole ester 2. [M+7]‐labeled levovirin valinate 6 (127 mg) was synthesized as a comparison MS reference compound from [M+6] triazole ester 3. [^14^C]‐Levovirin 7 and [^14^C]‐levovirin valinate 8 were synthesized to support metabolism studies. The synthesis of 7 was accomplished in 33% overall yield (35.4 mCi, 57 mCi/mmol) from Ba^14^CO~3~ and 8 was synthesized in 41% yield (12.5 mCi, 57 mCi/mmol) from 7. An efficient metallation/carbonation reaction was developed to synthesize [^14^C]‐triazole ester 4. Copyright © 2006 John Wiley & Sons, Ltd.

📜 SIMILAR VOLUMES

Syntheses of stable-isotope labeled [M+7
Syntheses of stable-isotope labeled [M+7] and [M+6] 2-(methylamino)imidazole
✍ Yinsheng Zhang 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 110 KB

## Abstract Stable isotope‐labeled 2‐methylaminoimidazole (M+7 and M+6) was required as an intermediate in the synthesis of mass labeled drug candidates. These two isotopomers were synthesized with total yields of 24 and 36%, respectively. Labeled 2‐aminoimidazole (M+4) was prepared from labeled is

The Use of Stable Isotope Labeling and L
The Use of Stable Isotope Labeling and Liquid Chromatography/Tandem Mass Spectrometry Techniques to Study the Pharmacokinetics and Bioavailability of the Antimigraine Drug, MK-0462 (Rizatriptan) in Dogs
✍ A. Barrish; T. V. Olah; G. J. Gatto; M. R. Dobrinska; J. D. Gilbert 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 428 KB 👁 2 views

## MK-0462 (rizatriptan) is a agonist being developed for the treatment of migraine. The assay for this substance in plasma and urine is based on HPLC with tandem mass spectrometry (MS/MS) detection. The procedure has been modified to include the simultaneous determination of the [triazole-"C,, "N3