M2025 Inhibiting Pancreatic Cancer Growth and Sensitizing the Tumor to Radiotherapy Through Downregulation of SP Proteins

Amphiregulin antisense oligonucleotide i

Amphiregulin antisense oligonucleotide inhibits the growth of T3M4 human pancreatic cancer cells and sensitizes the cells to EGF receptor-targeted therapy

✍ Hitoshi Funatomi; Jun Itakura; Toshiyuki Ishiwata; Ira Pastan; Stewart A. Thomps 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 French ⚖ 152 KB 👁 2 views

Human pancreatic cancers overexpress the epidermal growth factor (EGF) receptor (EGFR) and all 5 ligands that bind to this receptor, including amphiregulin. It is not known, however, whether amphiregulin contributes in an autocrine manner to enhance pancreatic cancer cell growth. Therefore, we used