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M2 and M3 muscarinic receptor-mediated contractions in longitudinal smooth muscle of the ileum studied with receptor knockout mice

✍ Scribed by Toshihiro Unno; Hayato Matsuyama; Takashi Sakamoto; Mai Uchiyama; Yusuke Izumi; Hiroyuki Okamoto; Masahisa Yamada; Jürgen Wess; Seiichi Komori


Book ID
110008806
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
222 KB
Volume
146
Category
Article
ISSN
0007-1188

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The muscarinic receptor subtype involved in human airway smooth muscle contraction was characterised for the first time, using subtype-selective muscarinic antagonists. It was demonstrated that methacholine-induced contraction of central (trachea) and peripheral (small bronchi) airway smooth muscle