M1963 Gene Therapy of Pancreatic Cancer Targeting the K-RAS Oncogene
β Scribed by Lisiansky, Victoria; Kazanov, Diana; Naumov, Inna; Shapira, Shiran; Kraus, Sarah; Arber, Nadir
- Book ID
- 123541177
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 50 KB
- Volume
- 138
- Category
- Article
- ISSN
- 0016-5085
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## Abstract Interferon alpha (IFNβΞ±) is used worldwide for the treatment of a variety of cancers. For pancreatic cancer, recent clinical trials using IFNβΞ± in combination with standard chemotherapeutic drugs showed some antitumor activity of the cytokine, but the effect was not significant enough t
Mutations in codon I 2 of K-ras occur in a high proportion of pancreatic cancer cases. Although there is evidence that p53 mutations also occur in this tumor, few studies have been reported to date and no comparison has been made of K-ras and p53 mutations in the same tissues. Single-strand conforma