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Lysosomal dysfunction in gangliosidoses results in secondary accumulation of proteins associated with neurodegeneration

✍ Scribed by Suraj Saksena; Yi Lun; Serene Keilani; Hadis Williams; Anthony Stevens; Eric Sjoberg; Richie Khanna; Ken Valenzano; David Lockhart; Sam Gandy; Brandon Wustman


Book ID
116989227
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
57 KB
Volume
102
Category
Article
ISSN
1096-7192

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Disorders with Lewy body (LB) formation, such as Parkinson's disease (PD) and dementia with Lewy bodies (DLB), are characterized by a-synuclein accumulation in the neuronal cell body. Recent studies have suggested that in addition to LBs, a-synuclein might accumulate more widely throughout the neuro