Lysosomal and mitochondrial enzyme activities in human lymphoid cell lines obtained from children with acute lymphoblastic leukemia and controls

Chimeric, divalent and tetravalent anti-

Chimeric, divalent and tetravalent anti-CD19 monoclonal antibodies with potent in vitro and in vivo antitumor activity against human B-cell lymphoma and pre-B acute lymphoblastic leukemia cell lines

✍ Xiao-Yun Liu; Laurentiu M. Pop; Lydia Tsai; Iliodora V. Pop; Ellen S. Vitetta 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 French ⚖ 295 KB

## Abstract CD19 is an attractive therapeutic target for treating human B‐cell tumors. In our study, chimeric (c) divalent (cHD37) and tetravalent (cHD37‐DcVV) anti‐CD19 monoclonal antibodies (MAbs) were constructed, expressed and evaluated for their binding to human 19‐positive (CD19^+^) tumor cel