The inactivation of calcium currents during nerve growth factor (NGF)-induced differentiation of rat pheochromocytoma (PCt2) cells was investigated. Whole cell calcium and barimn currents were recorded in PC12 cells using the patch-clamp method. A shift of the steady-state inactivation curve towards
β¦ LIBER β¦
Lysophosphatidylserine potentiates nerve growth factor-induced differentiation of PC12 cells
β Scribed by Sandra Lourenssen; Michael G Blennerhassett
- Book ID
- 117476688
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 282 KB
- Volume
- 248
- Category
- Article
- ISSN
- 0304-3940
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The lipid biomediator lysophosphatidic acid (LPA) elicits a unique response in hippocampal neurons, LPA induces neuronal apoptosis. This study explores the effects of LPA on cells with neuronal properties, nerve growth factor-differentiated PC6 cells, a clone of PC12 cells. LPA induced apoptosis in